Overview

You may have COVID-19 diagnostic testing done to find out if you're currently infected with the virus that causes coronavirus disease 2019 (COVID-19).

The U.S. Food and Drug Administration (FDA) approved these types of tests for diagnosing COVID-19:

  • RT-PCR test. Also called a molecular test, this COVID-19 test detects genetic material of the virus using a lab technique called reverse transcription polymerase chain reaction (RT-PCR). A health care professional collects a fluid sample by inserting a long nasal swab (nasopharyngeal swab) into your nostril and taking fluid from the back of your nose. A sample may be collected by using a shorter nasal swab (mid-turbinate swab) or a very short swab (anterior nares swab). In some cases, health care professional inserts a long swab into the back of your throat (oropharyngeal swab). Or you may spit into a tube to produce a saliva sample.

    Results may be available in minutes if analyzed onsite in 1 to 3 days — or longer in locations with test processing delays — if sent to an outside lab. RT-PCR tests are very accurate when properly performed by a health care professional, but the rapid test can miss some cases.

  • Antigen test. This COVID-19 test detects certain proteins in the virus. Using a long nasal swab to get a fluid sample, some antigen tests can produce results in minutes. Others may be sent to a lab for analysis.

    A positive antigen test result is considered accurate when instructions are carefully followed. But there's an increased chance of false-negative results — meaning it's possible to be infected with the virus but have a negative result. Depending on the situation, the health care provider may recommend a RT-PCR test to confirm a negative antigen test result.

A RT-PCR test called the Flu SC2 Multiplex Assay can detect any of three viruses at the same time: the COVID-19 virus, influenza A and influenza B (flu). Only a single sample is needed to check for all three viruses. This could be helpful during the flu season. But a negative result does not rule out the possibility of any of these infections. So the testing process may include more steps, depending on symptoms, possible exposures and your provider's clinical judgment.

Why it's done

In the U.S., a COVID-19 diagnostic test may be needed if:

  • You have COVID-19 symptoms, such as fever, cough, tiredness or shortness of breath.
  • You've had close contact with someone with COVID-19. Close contact means you've been within 6 feet (2 meters) of a person who has COVID-19, or you live with someone with COVID-19. If you've had close contact with someone who has the COVID-19 virus, get tested at least five days after you've had contact with them.
  • Your health care provider, other health care professional or your public health department recommends a test and you're not fully vaccinated.
  • You're required to take a test for screening purposes, such as at some schools or workplaces.

You don't need to be tested if you've had COVID-19 in the last three months.

Certain groups are considered high priority for diagnostic testing. These include people with COVID-19 signs and symptoms who:

  • Work in a health care facility or as first responders
  • Live or work in long-term care facilities, such as nursing homes, or other places where people are housed closely together, such as prisons or shelters
  • Are being cared for in a hospital

Other people may be given priority for testing depending on local health department guidelines for monitoring COVID-19 in individual communities.

Some people who have COVID-19 may not have symptoms (asymptomatic). But they can still spread the virus that causes COVID-19 to others. People with no symptoms can be tested. If people without symptoms have a positive test result, they should follow guidelines for self-isolation to help curb the spread of the virus.

The availability of COVID-19 diagnostic testing and where to get tested may vary depending on where you live and the recommendations of your local public health officials.

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Risks

There's a chance that your COVID-19 diagnostic test could return a false-negative result. This means that the test didn't detect the virus, even though you actually are infected with it. If you have symptoms, you risk unknowingly spreading the virus to others if you don't take proper precautions, such as wearing a face mask when appropriate. There's also a chance that a COVID-19 rapid antigen test can produce false-positive results if you don't follow the instructions carefully. False-positive results mean the test results show an infection when actually there isn't one.

The risk of false-negative or false-positive test results depends on the type and sensitivity of the COVID-19 diagnostic test, thoroughness of the sample collection, and accuracy of the lab analysis.

Be wary of any offers for at-home COVID-19 tests that the FDA has not cleared for use. They often give inaccurate results.

How you prepare

Whether or not you have symptoms, plan to wear a face mask to and from your provider's office or the testing center.

  • If you think you may have COVID-19, call health care provider's office or your local health department to review your symptoms and ask about testing before you go in. This way staff can prepare for your visit and wear personal protective equipment.
  • If you have no symptoms but you've been in close contact with someone who has COVID-19, follow the testing advice of your health care provider or public health department. Having a COVID-19 test at least 5 days after you had close contact to the person with COVID-19 is best. If you're tested too soon, the test may not detect the virus.

If you have no symptoms and don't think you've been in contact with someone with COVID-19, but you want to get tested, ask your health care provider or testing center whether and where testing is available. Or you can call your state or local health department or visit their website for information on testing.

What you can expect

For a COVID-19 diagnostic test, a health care professional takes a sample of mucus from your nose or throat, or a sample of saliva. The sample needed for diagnostic testing may be collected at your doctor's office, a health care facility or a drive-up testing center.

  • Nose or throat swab. A long nasal swab (nasopharyngeal swab) is recommended, though a shorter or very short nasal swab or throat swab is acceptable. A health care professional inserts a thin, flexible stick with cotton at the tip into your nose or brushes the swab along the back of your throat to collect a sample of mucus. This may be somewhat uncomfortable.

    For the nasal sample, swabbing may occur in both nostrils to collect enough mucus for the test. The swab remains in place briefly before being gently rotated as it's pulled out. The sample gets sealed in a tube and sent to a lab for analysis.

  • Saliva sample. Some locations offer saliva tests. While a saliva sample may be a bit less sensitive than a mucus sample that's taken using a long nasal swab, a saliva test is easier to do and often less uncomfortable. You spit into a tube several times to provide a sample of your saliva to test. The tube is sealed before being sent to a lab for analysis.

If you have a productive cough, your health care provider may collect a sputum sample, which contains secretions from the lungs, a part of the lower respiratory system. The virus is more concentrated in the nose and throat early in the course of the infection. But after more than five days of symptoms, the virus tends to be more concentrated in the lower respiratory system.

In addition to the COVID-19 diagnostic test, your health care provider may also test for other respiratory conditions, such as the flu, that have similar symptoms and could explain your illness.

The FDA granted emergency use authorization for certain at-home COVID-19 test kits, including one that tests for both COVID-19 and the flu. Some of these tests require a provider's prescription. You collect your own sample of nasal fluid or saliva at home and then send it to a lab to be rapidly analyzed. Some COVID-19 tests provide fast results at home without sending the sample to a lab.

You can buy some antigen tests over the counter with no prescription needed, though antigen tests are not considered as reliable as PCR tests. The benefits of an at-home test are you can take it at home and get quick results. It's a fast and easy way to test yourself as soon as you have symptoms or at least five days after you've been exposed to the COVID-19 virus. It's also an option if you want to make sure you don't have the virus before meeting in groups with others, to ensure you don't accidentally spread it. If you test negative, taking the test a second time a few days later can help ensure your test results are accurate.

The accuracy of each of these tests varies. So a negative test does not completely rule out having the COVID-19 virus. Only get an at-home test that's authorized by the FDA or approved by your doctor or local health department.

Supporting Your Child During COVID-19 Nasal Swab Testing

The purpose of this video is to prepare children for a COVID-19 nasal swab test, to help ease some of their potential fear and anxiety. When children are prepared to take a medical test, they become more cooperative and compliant, which creates a positive coping experience for them. This video has been made to be watched by children as young as 4 years old.

Jennifer Rodemeyer, Child Life Program Manager, Mayo Clinic: Hi, I'm Jennifer and I am a child life specialist at Mayo Clinic. My job is to help kids like you prepare for medical tests.

You may have heard there is a virus going around that can make people feel sick. A virus is a germ and it is so tiny you can't even see it.

Some people who get this virus can have a fever or a cough and may feel achy and tired, while some people can have this virus and not feel sick at all. People may get this virus from touching things. That's why it's important to wash your hands often with soap and water. The virus also can spread through a cough or a sneeze. So it's important to always cover your cough or sneeze.

Today, even though you may or may not be feeling sick, we will need to give you a test so we know how to best proceed with your medical care. This medical test will tell us if you have the virus.

When you go to take your test, the health care provider will wear special protective clothing. They wear this clothing to keep themselves and you safe from getting germs. They will wear a mask to cover their nose and mouth and a clear plastic shield to protect their eyes.

The most important thing you can do during your test is to sit perfectly still like a statue. To help make sure you don't move, your parent or caregiver will help keep you still and calm during your test. The health care provider needs to touch the inside of the back of your nose with a long, skinny Q-tip. To do this, you need to hold your chin up, then the health care provider will put the Q-tip in your nose for a short time to collect a sample.

While this happens you may feel like you want to push the Q-tip away, but it's really important to stay as still as possible so the health care provider can finish the test. The Q-tip will be in and out of your nose in a few seconds.

Some kids tell me that counting to 3 or taking a deep breath relaxes them before the test happens, and some tell me they like to hold on to their favorite stuffed animal or blanket. Maybe you have your own way to relax.

Remember that during the test, the most important thing to do is to keep your body perfectly still.

You may have many feelings seeing the health care provider wearing different clothing, but know this person is caring and wants to help you.

Thank you for helping us get this test done, so we know how to proceed with your medical care.

Results

Some facilities have rapid tests for COVID-19 diagnostic testing. In that case, you may get your results in less than an hour or on the same day that you're tested. Other facilities may have to send the test sample to an outside lab for analysis. If they need to send out the sample, your results may not be available until a few days later.

Your COVID-19 diagnostic test result could be positive or negative.

  • Positive result. This means you currently have an active infection with the virus that causes COVID-19. Take appropriate steps to care for yourself. Avoid spreading the virus to others.

    You'll need to self-isolate until: Your symptoms are improving, and it's been 24 hours since you've had a fever, and at least five days have passed since your symptoms first appeared. Wear a mask for five more days. If you don't have a fever and want to get tested after at least five days, you may do so. But if your test is positive, stay at home for five more days.

    If you have severe symptoms of COVID-19 or a health condition that lowers your ability to fight disease, your doctor may recommend that you stay in isolation longer. If you have a positive result but never developed symptoms, isolate for five days after the test and wear a mask for five more days.

  • Negative result. This means that you likely don't have an infection with the COVID-19 virus. But a false-negative test result could happen depending on the timing and quality of the test sample. If you have symptoms, stay away from others. Your doctor may recommend repeat testing if you continue to have symptoms.

    Even if you test negative, you could become infected in the future. So it's important to follow guidelines such as face mask use in indoor public spaces and regular hand-washing to avoid potential spread.

Contact tracing

If you test positive for the COVID-19 virus, you may be asked to participate in contact tracing. Contact tracing plays a key role in limiting the spread of infectious diseases, as it can help limit virus spread. Public health staff may ask you for a list of anyone you had close contact with during the time you may have been contagious. Public health staff may contact these people. They may suggest that your contacts watch for symptoms, get COVID-19 tests or stay at home and away from others if they're not vaccinated.

Quarantine recommendations

If you've had close contact with someone who has COVID-19 and you're not fully vaccinated, stay at home and away from others (quarantine) for five days after the exposure. Watch to see if you develop COVID-19 symptoms. Then wear a mask for five more days. If you can't quarantine, wear a mask for 10 days. Try to stay away from people in your household. If you have symptoms, self-isolate.

If you have had COVID-19 in the last three months or gotten all recommended vaccine doses, including boosters and additional primary shots, you generally don't need to quarantine. But wear a mask for 10 days.

If you've received the recommended vaccine doses but not a booster, stay home for five days. Get tested after at least five days. And wear a mask for five more days. If you're not able to stay home, wear a mask for 10 days.

Get tested at least five days after the exposure, even if you don't have symptoms.

Contact your health care provider or local health department for advice on testing and quarantine recommendations.

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Feb. 23, 2022
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